Introduction Hemorrhagic cystitis (HC) is a frequent complication of hematopoietic stem cell transplantation (HSCT). The reported frequency changes mainly with the definition (according to inclusion or exclusion of microscopic hematuria) and preventive manipulations. It may occur in the early or late posttransplant period and can promote sometimes severe morbidity. Several risk factors are reported to date, which include drugs, chemical toxins, infection, and pelvic irradiation [1,2]. It is mostly self-limited, and supportive treatment with hyperhydration and increased transfusion can be sufficient . To facilitate the urinary flow, placement of urinary catheter is sometimes needed for intermittent or continuous bladder irrigation. Instillation of agents such as alum, silver nitrate, prostaglandin (PG) or formalin is the therapeutic intervention used to halt hemorrhage in severe HC [4-7].