Abstract: Crude extracts (in 50% v/v, ethanol) of Wax negundo L. (Verbenaceae), Argemone maxicana L. (Papaveraceae), Cuminum cyminum L. (Apiaceae), Moringa oleifera Lamk (Moringaceae), Solanum virginianum L. (Solanaceae), Datura metal L. (Solanaceae) and Zingiber officinale Rosc. (Zingiberaceae) were screened for antioxidant and anti-inflammatory related activities. The antioxidant potentials were determined by performing reducing ability assay, 2, 2-diphenyl-l-picryl hydrazine (DPPH) radical and OH radical scavenging activity along with inhibition of polyphenol oxidase: a metal containing model oxidizing enzyme. The amount of major antioxidative substances like phenolics and vitamin C were estimated. The anti-inflammatory related activities such as inhibition of trypsin, [beta]-glucuronidase and conjugated then formation were carried out to assess the possible anti-inflammatory potential of the selected botanicals. The result of the present investigations show that the plant samples under study were found to be effective reducing agents along with considerable DPPH radical scavenging activity. With few exceptions all the plant samples showed moderate OH radical scavenging potentials and significantly inhibited the generation of hydroperoxides. All the tested plants showed moderate to poor profiles towards inhibition of trypsin, [beta]-glucuronidase and PPO. In the present growing herbal market worldwide the standardisation, authentication and quality control of medicinal plants has remained a major and critical issue in the focus of converting botanical materials into medicines. The results of the present findings may be useful in this context. Keywords: Traditional medicine, medicinal plants, antioxidants, anti-inflammatory, enzyme inhibition, Ayurveda.