Association of Gene Polymorphisms with Development of Cancer Risk Or Their Protective Role Associated with Some Mutant Alleles (Commentary)

Association of Gene Polymorphisms with Development of Cancer Risk Or Their Protective Role Associated with Some Mutant Alleles (Commentary)

Over the past decade, due to the advent of human genome project and its overwhelming success, there has been a great deal of interest in defining genetic polymorphisms and finding their associations with development of disease risks. However, to keep a consistent and balanced growth in this arena, one needs to have an in-depth knowledge about the extent of variations in phenotypes and their potential. Answers must be sought for questions, such as “In their ability to handle and rectify the DNA damage, how much do each individual vary from one another? To what extent do these variations play a role in making any individual susceptible to developing a higher cancer risk? And lastly, but more importantly, how far and to what limit genetic polymorphism can be held responsible for such variations?”. In this issue, Mitra et al (1) report the biology of human cancer in relation to genetic polymorphisms. For the first time in 1969, the crucial role played by DNA repair in preventing cancer was conclusively demonstrated by Cleaver (2), when he identified a defect in the pathway of excision repair among patients with Xeroderma Pigmentosum.

Association of Gene Polymorphisms with Development of Cancer Risk Or Their Protective Role Associated with Some Mutant Alleles (Commentary)



Here is Download Link

Human Genome Epidemiology


Human Genome Epidemiology Read Online Download

Author by : Muin J. Khoury
Languange Used : en
Release Date : 2004
Publisher by : Oxford University Press






Landmark Papers In Internal Medicine


Landmark Papers In Internal Medicine Read Online Download

Author by : Harold C. Sox
Languange Used : en
Release Date : 2009
Publisher by : ACP Press






Application Of Biomarkers In Cancer Epidemiology


Application Of Biomarkers In Cancer Epidemiology Read Online Download

Author by : P. Toniolo
Languange Used : en
Release Date : 1997
Publisher by : International Agency for Research on Cancer (I A R C)






Clearing The Smoke


Clearing The Smoke Read Online Download

Author by : Committee to Assess the Science Base for Tobacco Harm Reduction
Languange Used : en
Release Date : 2001-10-01
Publisher by : National Academies Press






Abc Of Colorectal Cancer


Abc Of Colorectal Cancer Read Online Download

Author by : Annie M. Young
Languange Used : en
Release Date : 2011-09-09
Publisher by : John Wiley & Sons






Single Nucleotide Polymorphisms


Single Nucleotide Polymorphisms Read Online Download

Author by : Anton A. Komar
Languange Used : en
Release Date : 2012-02-25
Publisher by : Humana Press






Environmental Factors Genes And The Development Of Human Cancers


Environmental Factors Genes And The Development Of Human Cancers Read Online Download

Author by : Deodutta Roy
Languange Used : en
Release Date : 2010-09-11
Publisher by : Springer Science & Business Media






Leave a Reply

Your email address will not be published. Required fields are marked *