Background & objectives: Individuals infected with HIV-1 have higher levels of chemokine producing cells compared to uninfected individuals. It is important to know the changes in chemokine levels associated with rate of progression of disease. There is a paucity of information on the plasma chemokines in HIV-1 infected individuals from India. We therefore carried out this study to estimate the levels of three chemokines namely macrophage inflammatory protein alpha (MIP1[alph]), MIP1[beta] and RANTES, in relation to disease status in HIV-1 infected individuals and compared with uninfected individuals. Methods: RANTES and MIP1[alpha] were estimated using ELISA in 114 HIV-1 infected and 30 controls, whereas MIP1[beta] was estimated in 101 HIV infected individuals only and 30 controls. The values were compared to the T cell subsets, HIV-1 viral loads and plasma cytokines (interferon gamma and interleukin-10).