Drug-Resistant Tuberculosis in Children (Original Articles)

Drug-Resistant Tuberculosis in Children (Original Articles)

Drug-resistant tuberculosis (TB), and especially multidrug-resistant (MDR) TB (i.e. resistance to isoniazid and rifampicin with or without resistance to other drugs) or extensively drug-resistant (XDR) TB (i.e. MDR resistance plus resistance to the fluoroquinolones and one of the second-line injectables–kanamycin, amikacin or capreomycin), (1) has very important implications for affected children and the TB control programme. These children are difficult to manage because of the increased adverse effects of the second-line anti-TB drugs and the prolonged duration of treatment. Furthermore, they are often diagnosed late because the history of a drug-resistant contact was not obtained or responded to. Children mainly have paucibacillary disease, which means that diagnosis of a child, especially with MDR TB, usually points to recent transmission in the community and therefore a failure of the TB control programme. Infectiousness of drug-resistant Mycobacterium tuberculosis strains

Drug-Resistant Tuberculosis in Children (Original Articles)

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