Evaluation of a Rapid Screening Test for Rifampicin Resistance in Re-Treatment Tuberculosis Patients in the Eastern Cape (Original Articles)

Evaluation of a Rapid Screening Test for Rifampicin Resistance in Re-Treatment Tuberculosis Patients in the Eastern Cape (Original Articles)

Background and objectives. Patients with multidrug-resistant (MDR) tuberculosis (TB) are at high risk of treatment failure. It is anticipated that early identification of MDR-TB and appropriate treatment will improve patient outcome and disease control. We evaluated the rapid detection of rifampicin resistance in previously treated TB patients, directly from acid-fast bacilli (AFB)-positive sputum using a phage-based test, FASTPlaque-Response (Biotec Laboratories Ltd, Ipswich, UK). The ability of rifampicin resistance to predict MDR-TB was also determined. Design. A prospective study was done comparing performance of the rapid phage test with conventional culture and drug susceptibility testing (DST) in AFB-positive TB patients. Setting. Five primary health clinics and one TB referral centre in the Port Elizabeth Metropolitan area, Eastern Cape.

Evaluation of a Rapid Screening Test for Rifampicin Resistance in Re-Treatment Tuberculosis Patients in the Eastern Cape (Original Articles)



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