Helicobacter Pylori Prevalence in Dyspeptic Patients in the Eastern Cape Province–Race and Disease Status (Original Articles) (Report)

Helicobacter Pylori Prevalence in Dyspeptic Patients in the Eastern Cape Province--Race and Disease Status (Original Articles) (Report)

Helicobacter pylori is the principal species of the genus Helicobacter that inhabits the gastric mucosa of the human stomach. It chronically infects billions of people worldwide, (1-3) and is responsible for one of the most frequent chronic bacterial infections involving more than 50% of the world’s population. (4) H. pylori is one of the most genetically diverse of bacterial species, and is a major cause of at least 90% of duodenal ulcers (DUs), 70% of gastric ulcers (GUs), non-ulcer dyspepsia (NUD) and gastro-oesophageal reflux disease (GORD). (5,6) It plays a role in adenocarcinoma of the distal stomach, mucosa-associated lymphoid tissue lymphoma (MALT) and primary gastric non-Hodgkin’s lymphoma, in many societies. (3,7) H. pylori’s ability to adhere, invade and evade host defences and cause tissue damage is largely due to its production of colonisation and virulence factors. (8) The prevalence of H. pylori infection increases with advancing age and is higher in developing countries and among low socio-economic populations, probably owing to conditions that favour the infection, such as poor hygiene, crowded living conditions, and inadequate or no sanitation. (1,9-11)

Helicobacter Pylori Prevalence in Dyspeptic Patients in the Eastern Cape Province--Race and Disease Status (Original Articles) (Report)



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