Human Papillomavirus Testing and Reporting Rates: Practices of Participants in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytology in 2006 (CAP Laboratory Improvement Programs) (Report)
Since 1994, the College of American Pathologists (CAP) has used survey questionnaires to assess practice patterns in cervicovaginal cytology. (1-5) These surveys have documented the widespread implementation of the first 2 versions of the Bethesda system, reporting rates for various cervical cytology categories and important benchmarking data for quality assurance. In 2003, human papillomavirus (HPV) testing practices were investigated. (5) Since the last CAP Supplemental Questionnaire, HPV testing has become more widely available and is performed sin some cytology laboratory units. A CAP Q-Probe was conducted in 2005 to assess use of HPV testing in cases of atypical squamous cells of undetermined significance (ASC-US) to establish potential HPV benchmarking data in this most highly prevalent positive cytologic category. (6) Oncogenic or high-risk HPV (HR-HPV) test is most familiar to practitioners as a concurrent, adjunctive test when a woman has an ASC-US Papanicolaou (Pap) test. (7) Recent management guidelines stipulate that a positive HR-HPV test is a cost-effective triage method for colposcopy in women older than 20 years of age with a Pap test demonstrating ASC-US. High-risk HPV testing in adolescents (women 20 years and younger) is not acceptable; any HR-HPV test results in adolescents should be ignored when planning for management. (8)
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