Impact of Pallidotomy on Physiological Articulation Function and Speech Intelligibility in Parkinson Disease.
The objective of this study was to evaluate the effects of posteroventral pallidotomy on perceptual and physiological measures of articulatory function and speech intelligibility in Parkinson disease (PD). The study examined 11 participants with PD who under-went posteroventral pallidotomy. Physiological measures of lip and tongue function and perceptual measures of speech intelligibility were obtained prepallidotomy and 3 months postpallidotomy. The participants with PD were also assessed on the Unified Parkinson’s Disease Rating Scale (UPDRS; Part III). In addition, the study included a group of 16 participants with PD who did not undergo pallidotomy and a group of 30 nonneurologically impaired participants. Analyses of physiological articulatory function and speech intelligibility did not reveal corresponding improvements in motor speech function as observed in general limb motor function postpallidotomy. Overall, individual reliable change analyses revealed that the majority of surgical PD participants demonstrated no reliable change on perceptual and physiological measures of articulation. The current study revealed preliminary evidence that articulatory function and speech intelligibility did not change following posteroventral pallidotomy in a group of individuals with PD. **********