In Situ Detection of Inflammatory Cytokines and Apoptosis in Pemphigus Foliaceus Patients (Report)

In Situ Detection of Inflammatory Cytokines and Apoptosis in Pemphigus Foliaceus Patients (Report)

Endemic pemphigus foliaceus (EPF), or fogo selvagem, is a chronic autoimmune disease (1)fc characterized by the formation of intraepidermal blisters, which are attributed to the presence of immunoglobulin G4 (IgG4) and IgG1 autoantibodies against desmoglein 1 (2) that reduce the adhesion between keratinocytes. (3) In addition to the presence of autoantibodies, a high production of cytokines involved in the inflammatory response, such as interleukin 1 (IL-1) and tumor necrosis factor [alpha] (TNF-[alpha]), by blood cells has been demonstrated in both pemphigus foliaceus and pemphigus vulgaris. (4,5) Recently, the role of apoptosis, a physiologicmechanism of cell death, in blister formation has been investigated. Studies analyzing skin samples from patients with pemphigus vulgaris have demonstrated the presence of apoptosis, which can be induced in vitro in keratinocytes by patient antibodies. (6) Apoptosis can also be induced by pathways that depend on the activation of the cellular immune response through Fas/Fas-L and TNFR, pathways that are involved in both tissue injuries and control mechanisms of the immune response. (7,8)

In Situ Detection of Inflammatory Cytokines and Apoptosis in Pemphigus Foliaceus Patients (Report)

In Situ Detection of Inflammatory Cytokines and Apoptosis in Pemphigus Foliaceus Patients (Report) | | 4.5