In Vitro Effect of Fluoroquinolones Against Mycobacterium Tuberculosis Isolates from Agra & Kanpur Region of North India.

In Vitro Effect of Fluoroquinolones Against Mycobacterium Tuberculosis Isolates from Agra & Kanpur Region of North India.

Background & objectives: Fluoroquinolones (FQs) are important drugs used for treatment of drug resistant tuberculosis and are also now being considered as first line drugs to shorten the duration of treatment of tuberculosis (TB). In order to find out useful FQs for treatment of tuberculosis, the comparative efficacy of five FQs, namely, ofloxacin (OFL), ciprofloxacin (CIP), sparfloxacin (SPX), gatifloxacin (GAT) and levofloxacin (LEVX) was studied against Mycobacterium tuberculosis (MTB) isolates obtained from both treated and untreated patients from Agra and Kanpur regions of north India. Methods: A total of 162 MTB isolates [including 110 MTB isolates obtained from untreated patients (Cat-I) and 52 isolates from treated patients (Cat-II)] were tested for their susceptibilities to FQs using standard minimum inhibitory concentration (MIC) method on Lowenstein-Jensen medium.

In Vitro Effect of Fluoroquinolones Against Mycobacterium Tuberculosis Isolates from Agra & Kanpur Region of North India.



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