1. Introduction These guidelines for the clinical management and laboratory investigation of venous thrombo-embolism (VTE) in neonates and children reflect current best practice. Recommendations presented are in accordance with the more comprehensive evidence-based guidelines for paediatric antithrombotic therapy, including the American College of Chest Physicians (ACCP) guidelines, the United Kingdom paediatric stroke guidelines and the American Heart Association guidelines for paediatric stroke. (1-6) Many of the recommendations are Grade 2C, indicating the lack of strong evidence (Table 1). The most current paediatric recommendations are extrapolated from adult trials; therefore, management should be individualised in consultation with a haematologist with appropriate consideration for the risk/ benefit ratio of each patient. Drug recommendations are based on Medicines Control Council registration at the time of publication.