Future Uses Of The Department Of Defense Joint Pathology Center Biorepository

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Future Uses Of The Department Of Defense Joint Pathology Center Biorepository


Future Uses Of The Department Of Defense Joint Pathology Center Biorepository
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Future Uses Of The Department Of Defense Joint Pathology Center Biorepository


Future Uses Of The Department Of Defense Joint Pathology Center Biorepository
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2013-01-13



Future Uses Of The Department Of Defense Joint Pathology Center Biorepository written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-13 with Medical categories.


Founded during the Civil War as the Army Medical Museum, the Armed Forces Institute of Pathology (AFIP) amassed the world's largest collection of human pathologic specimens and was considered a premier consultation, education, and research facility by the end of the 20th century. Samples from the AFIP were instrumental in helping to solve public health mysteries, such as the sequence of the genome of the 1918 influenza virus that killed more than 40 million people worldwide. In 2005, the federal Base Realignment and Closure Commission recommended that the AFIP be closed, and its biorepository was transferred to the newly created Joint Pathology Center. During the transition, the Department of Defense asked the IOM to provide advice on operating the biorepository, managing its collection, and determining appropriate future use of specimens for consultation, education, and research. Future Uses of the Department of Defense Joint Pathology Center Biorepository, the IOM proposes a series of protocols, standards, safeguards, and guidelines that could help to ensure that this national treasure continues to be available to researchers in the years to come, while protecting the privacy of the people who provided the materials and maintaining the security of their personal information.

Specimen Science


Specimen Science
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Author : Suzanne M. Rivera
language : en
Publisher: MIT Press
Release Date : 2017-09-29



Specimen Science written by Suzanne M. Rivera and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-29 with Medical categories.


Advances in medicine often depend on the effective collection, storage, research use, and sharing of human biological specimens and associated data. But what about the sources of such specimens? When a blood specimen is drawn from a vein in your arm, is that specimen still you? Is it your property, intellectual or otherwise? Should you be allowed not only to consent to its use in research but also to specify under what circumstances it may be used? These and other questions are at the center of a vigorous debate over the use of human biospecimens in research. In this book, experts offer legal, regulatory, and ethical perspectives on balancing social benefit and human autonomy in biospecimen research. After discussing the background to current debates as well as several influential cases, including that of Henrietta Lacks, the contributors consider the rights, obligations, risks, and privacy of the specimen source; different types of informed consent under consideration (broad, blanket, and specific); implications for special patient and researcher communities; and the governance of biospecimen repositories and the responsibilities of investigators. ContributorsRebecca A. Anderson, Heide Aungs, Avery Avrakotos, Mark Barnes, Jill Barnholtz-Sloan, Benjamin Berkman, Barbara E. Bierer, Mark A. Borreliz, Jeffrey R. Botkin, Dan Brock, Ellen Wright Clayton, I. Glenn Cohen, Lisa Eckstein, Barbara J. Evans, Emily Chi Fogler, Nanibaa' A. Garrison, Pamela Gavin, Aaron J. Goldenberg, Christine Grady, Kate Gallin Heffernan, Marylana Saadeh Helou, Sara Chandros Hull, Elisa A. Hurley, Steven Joffe, Erin P. Johnson, Julie Kaneshiro, Aaron S. Kesselheim, Isaac Kohane, David Korn, Russell Korobkin, Bernard Lo, Geoffrey Lomax, Kimberly Hensle Lowrance, Holly Fernandez Lynch, Bradley A. Malin, Karen J. Maschke, Eric M. Meslin, P. Pearl O'Rourke, Quinn T. Ostrom, David Peloquin, Rebecca Pentz, Jane Perlmutter, Ivor Pritchard, Suzanne M. Rivera, Erin Rothwell, Andrew P. Rusczek, Rachel E. Sachs, Carol Weil, David Wendler, Benjamin Wilfond, Susan M. Wolf

Assessment Of The Department Of Veterans Affairs Airborne Hazards And Open Burn Pit Registry


Assessment Of The Department Of Veterans Affairs Airborne Hazards And Open Burn Pit Registry
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-04-28



Assessment Of The Department Of Veterans Affairs Airborne Hazards And Open Burn Pit Registry written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-28 with Medical categories.


Military operations produce a great deal of trash in an environment where standard waste management practices may be subordinated to more pressing concerns. As a result, ground forces have long relied on incineration in open-air pits as a means of getting rid of refuse. Concerns over possible adverse effects of exposure to smoke from trash burning in the theater were first expressed in the wake of the 1990â€"1991 Gulf War and stimulated a series of studies that indicated that exposures to smoke from oil-well fires and from other combustion sources, including waste burning, were stressors for troops. In January 2013, Congress directed the Department of Veterans Affairs (VA) to establish and maintain a registry for service members who may have been exposed to toxic airborne chemicals and fumes generated by open burn pits. Assessment of the Department of Veterans Affairs Airborne Hazards and Open Burn Pit Registry analyzes the initial months of data collected by the registry and offers recommendations on ways to improve the instrument and best use the information it collects. This report assesses the effectiveness of the VA's information gathering efforts and provides recommendations for addressing the future medical needs of the affected groups, and provides recommendations on collecting, maintaining, and monitoring information collected by the VA's Airborne Hazards and Open Burn Pit Registry.

Veterans And Agent Orange


Veterans And Agent Orange
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-01-20



Veterans And Agent Orange written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-20 with Medical categories.


From 1962 to 1971, the U.S. military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academies of Sciences, Engineering, and Medicine was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations were conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 11 (2018) examines peer-reviewed scientific reports concerning associations between various health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published between September 30, 2014, and December 31, 2017, and integrates this information with the previously established evidence database.

Respiratory Health Effects Of Airborne Hazards Exposures In The Southwest Asia Theater Of Military Operations


Respiratory Health Effects Of Airborne Hazards Exposures In The Southwest Asia Theater Of Military Operations
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-09-23



Respiratory Health Effects Of Airborne Hazards Exposures In The Southwest Asia Theater Of Military Operations written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-23 with Medical categories.


More than 3.7 million U.S. service members have participated in operations taking place in the Southwest Asia Theater of Military Operations since 1990. These operations include the 1990-1991 Persian Gulf War, a post-war stabilization period spanning 1992 through September 2001, and the campaigns undertaken in the wake of the September 11, 2001, attacks. Deployment to Iraq, Kuwait, Saudi Arabia, Bahrain, Gulf of Aden, Gulf of Oman, Oman, Qatar, the United Arab Emirates, and Afghanistan exposed service members to a number of airborne hazards, including oil-well fire smoke, emissions from open burn pits, dust and sand suspended in the air, and exhaust from diesel vehicles. The effects of these were compounded by stressors like excessive heat and noise that are inevitable attributes of service in a combat environment. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations reviews the scientific evidence regarding respiratory health outcomes in veterans of the Southwest Asia conflicts and identifies research that could feasibly be conducted to address outstanding questions and generate answers, newly emerging technologies that could aid in these efforts, and organizations that the Veterans Administration might partner with to accomplish this work.

Multigenic And Induced Systemic Resistance In Plants


Multigenic And Induced Systemic Resistance In Plants
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Author : Tuzun Sadik
language : en
Publisher: Springer
Release Date : 2008-11-01



Multigenic And Induced Systemic Resistance In Plants written by Tuzun Sadik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Science categories.


Plants have developed very sophisticated mechanisms to combat pathogens and pestsusingtheleastamountofreservedorgeneratedenergypossible. Theydothis by activating major defense mechanisms after recognition of the organisms that are considered to be detrimental to their survival; therefore they have been able to exist on Earth longer than any other higher organisms. It has been known for the past century that plants carry genetic information for inherited resistance against many pathogenic organisms including fungi, bacteria, and viruses, and that the relationship between pathogenic organisms and hosts plants are rather complex and in some cases time dependent. This genetic information has been the basis for breeding for resistance that has been employed by plant breeders to develop better-yielding disease resistant varieties, some of which are still being cultivated. Single gene resistance is one type of resistance which has been extensively studied by many research groups all around the world using biotechnological methodologies that have been the subject of many books and journal articles; therefore, it is beyond the scope of this book. This type of resistance is very effective, although it can be overcome by the pressure of pathogenic organisms since it depends on interaction of a single elicitor molecule from the pathogen with a single receptor site in the host.

Het Onsterfelijke Leven Van Henrietta Lacks


Het Onsterfelijke Leven Van Henrietta Lacks
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Author : Rebecca Skloot
language : nl
Publisher: Nieuw Amsterdam
Release Date : 2017-11-14



Het Onsterfelijke Leven Van Henrietta Lacks written by Rebecca Skloot and has been published by Nieuw Amsterdam this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-14 with History categories.


Haar naam was Henrietta Lacks, maar de medische wereld kent haar als HeLa. In de jaren '50 werden haar kankercellen zonder dat zij dat wist bij haar weggenomen. Met behulp van deze cellen, die letterlijk onsterfelijk zijn, werden de meest uiteenlopende geneeskundige ontdekkingen gedaan en rond de verkoop ervan ontstond een miljoenenindustrie. Het leven van Henrietta bleef echter vrijwel onbekend en ook haar familie wist tot ruim dertig jaar geleden niet van het bestaan van de cellen af. Rebecca Skloot vertelt het verhaal van de 'HeLa-cellen', maar laat ons vooral ook kennis maken met Henrietta, haar verleden en haar familie, die nog steeds worstelt met de nalatenschap van de cellen. Ze laat zien dat het verhaal van de familie Lacks onlosmakelijk verbonden is met de duistere geschiedenis van het experimenteren met Afrikaans-Amerikanen, het ontstaan van de ethiek binnen de biologie en de juridische strijd over de vraag of we de baas zijn over de materie waarvan we zijn gemaakt.