Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives

Download Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives book now. This site is like a library, Use search box in the widget to get ebook that you want.

If the content Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives not Found or Blank , you must refresh this page manually or visit our sister site

Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives


Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives
DOWNLOAD
READ ONLINE


File Size : 55,5 Mb
Total Download : 648

Download Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives PDF/ePub, Mobi eBooks by Click Download or Read Online button. Instant access to millions of titles from Our Library and it’s FREE to try! All books are in clear copy here, and all files are secure so don't worry about it.



Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives


Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives
DOWNLOAD
READ ONLINE


File Size : 52,5 Mb
Total Download : 361

Author : Morena Zusso
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-14



Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives written by Morena Zusso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-14 with categories.




The Role Of Inflammation In The Etiology And Treatment Of Schizophrenia


The Role Of Inflammation In The Etiology And Treatment Of Schizophrenia
DOWNLOAD
READ ONLINE


File Size : 43,5 Mb
Total Download : 691

Author : Ole Köhler-Forsberg
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-23



The Role Of Inflammation In The Etiology And Treatment Of Schizophrenia written by Ole Köhler-Forsberg and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-23 with Medical categories.




Radiation And The Immune System Current Knowledge And Future Perspectives


Radiation And The Immune System Current Knowledge And Future Perspectives
DOWNLOAD
READ ONLINE


File Size : 46,8 Mb
Total Download : 950

Author : Katalin Lumniczky
language : en
Publisher: Frontiers Media SA
Release Date : 2018-05-03



Radiation And The Immune System Current Knowledge And Future Perspectives written by Katalin Lumniczky and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-03 with categories.


For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in the tumor microenvironment, and at systemic level. These observations paved the way for studies exploring optimal combinations of radiotherapy and immunotherapy in order to achieve a synergistic effect to eradicate tumors. However, not all interactions between radiation and the immune system are beneficial, as it was recognized that many of radiation-induced late side effects are also of immune and inflammatory nature. Currently perhaps the most studied field of research in radiation biology is focused around the biological effects of low doses, where many of the observed pathophysiological endpoints are due to mechanisms other than direct radiation-induced cell killing and are immune-related. Finally, it must not be forgotten that the interactions between the ionizing radiations and the immune system are bi-directional, and activation of the immune system also influences the outcome of radiation exposure. This Research Topic brings together 23 articles and aims to give an overview of the complex and very often contradictory nature of the interactions between ionizing radiation and the immune system. Due to its increasing penetrance in the population both through medical diagnostic or environmental sources or during cosmic travel low dose ionizing radiation exposure is becoming a major epidemiological concern world-wide. Several of the articles within the Research Topic specifically address potential long-term health consequences and the underlying mechanisms of low dose radiation exposure. A major intention of the Editors was also to draw the attention of the non-radiobiological scientific community on the fact that ionizing radiation is by far more than purely an immune suppressing agent.

Neuroimaging


Neuroimaging
DOWNLOAD
READ ONLINE


File Size : 42,8 Mb
Total Download : 840

Author : Yongxia Zhou
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-06-24



Neuroimaging written by Yongxia Zhou and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-24 with Medical categories.


In vivo brain neuroimaging with cutting-edge technologies has achieved great success with high spatial and temporal resolutions. Several distinct medical imaging perspectives such as disease neurobiology, multimodal imaging techniques and applications, large-size clinical trials of neuro-oncology, and bioinformatics with illustrative examples and comprehensive summaries could expand our knowledge of neuroimaging mechanism, methodologies, and applications. This book highlights the possibility and achievement of early detection and multiple neuroimaging biomarkers based on various features for pathophysiological probing and therapeutic prevention. It examines the use of neuroimaging techniques such as magnetic resonance imaging (MRI), electroencephalography (EEG), and near-infrared resonance spectroscopy (NIRS) with specific and innovative biomedical applications. It provides thorough reviews, accurate descriptions, and confirmative evidences of many related important research topics together with up-to-date imaging network management.

Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies


Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies
DOWNLOAD
READ ONLINE


File Size : 43,6 Mb
Total Download : 938

Author : Mauro Perretti
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-04



Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies written by Mauro Perretti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-04 with categories.


In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this series of articles we foresee the birth of Resolution Pharmacology. The 16 contributions presented herein confirm the broad relevance of pro-resolving physio-pharmacology with the description of pro-resolving mechanisms in distinct diseases, from atherosclerosis and heart infarct, to cystic fibrosis and diabetes. This testifies on one hand the fundamental role that inflammatory mechanisms play in virtually all pathological settings and, on the other hand, the great potential that a novel approach to anti-inflammatory therapy by exploiting resolution mediators and targets may have. Thus, while there is broad recognition that evidence-based interventions have transformed cardiovascular, inflammation and endocrine care, new therapies are still needed for growing numbers of patients with unmet needs. As an example, an estimated 17 million people world-wide die annually of cardiovascular diseases, particularly heart attacks and strokes. Cardiovascular diseases occur almost equally in men and women and are the leading cause of death and morbidity worldwide. It is estimated that only 1/1,000 compounds entering preclinical testing are then trialled in man and the actual cost of developing a new therapeutic into clinical practice has grown exponentially over the past two decades (estimated $1.2B). Over the last 20 years or more, scientists have appreciated the biology of the resolution of inflammation, which provides a new paradigm in our understanding of the inflammatory process with the appreciation of genetic, molecular and cellular mechanisms that are engaged to actively resolve inflammation. The ‘resolution of acute inflammation’ is enabled by counter-regulatory checkpoints to terminate the host reaction while at the same time promoting healing and repair. The potential of lipid mediators to enact pro-resolving effects in the context of cystic fibrosis is presented by Recchiuti et al., while Fredman reasons on the potential for these molecules in atherosclerosis. This resonates well with the contributions from Bäck and colleagues who have focused on pro-resolving receptors to offer vasculo-protection in intimal hyperplasia and more generally in cardiovascular disease. On the same vein is the scholar contribution of Leoni and Soehnlein who focus on heart disease, with Qin et al. presenting the latest findings on the effect of an Annexin A1-derived peptide in myocardial infarction. Hansen et al. and de Gaetano et al. bring in the complexity of diabetes and associated morbidity with a focus on specialised pro-resolving lipid mediators but also introducing the potential of dietary approaches. As the western diet favours disease, an omega-3 rich diet can lead to higher availability of lipid mediators to afford tissue protection if not reverting its pathological status. Docosahexaenoic acid and its bioactive derivatives are endowed with potent anti-nociceptive properties following bone fracture, as shown by Zhang et al. The broad relevance of the pharmacological approach reaches the skin with Resolvin D1 protecting against UV irradiation (Saito et al.). Reduced skin inflammation is also achieved with an Annexin A1 peptide that impacts on the outcome of heterologous transplantation (Lacerda et al.). Indeed, modulating the phenotype of immune cells can provide long lasting beneficial outcomes, as attained with CDK inhibitors (Cartwright et al.) and PI3K inhibitors in experimental gout (Galvao et al.). Such an effect is also achieved with a third group of pro-resolving therapeutics, the melanocortin receptor agonists, with important modulation of macrophage reactivity (Patruno et al.) with Spana et al., providing new pharmacology following selective activation of the MC1 receptor. Finally, Hopkin et al. discuss the potential for targeting immune cell trafficking as a way to control immune mediated diseases, bringing in not only pro-resolving mediator agonists, but also approaches to reduce chemo/cytokine gradients or modulating S1P and 11-beta hydroxysteroid dehydrogenase. Finally, we wish to highlight that this wealth of science has also bought to the forefront specific pro-resolving receptors (including FPR2/ALX, GPR32, ChemR23 and MC1), all G protein coupled receptors that are therefore amenable to pharmacological exploitation for drug discovery programmes. We see that not only agonists to the receptors can be developed, some of them modelled on the natural ligands (e.g. resolvins, lipoxins, Annexin A1-derived peptides or melanocortin peptides), but also that the creativity of this pharmacology can be attained through biased ligands and positive allosteric modulators. Deep knowledge of pro-resolving receptor biology and their cell-specific signalling can accelerate the generation of novel anti-inflammatory depicted on the resolution of inflammation. In conclusion, with this eBook, we propose time is ready to exploit the concepts of resolution and use its targets and mediators for the identification of better drugs to establish ‘Resolution Pharmacology’. We predict Resolution Pharmacology will represent an important innovation in the way common diseases will be treated in the next decades of this millennium.

Issues In Pharmacology Pharmacy Drug Research And Drug Innovation 2011 Edition


Issues In Pharmacology Pharmacy Drug Research And Drug Innovation 2011 Edition
DOWNLOAD
READ ONLINE


File Size : 43,9 Mb
Total Download : 849

Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09



Issues In Pharmacology Pharmacy Drug Research And Drug Innovation 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.


Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues In Life Sciences Cellular Biology 2011 Edition


Issues In Life Sciences Cellular Biology 2011 Edition
DOWNLOAD
READ ONLINE


File Size : 48,8 Mb
Total Download : 893

Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09



Issues In Life Sciences Cellular Biology 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.


Issues in Life Sciences: Cellular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Cellular Biology. The editors have built Issues in Life Sciences: Cellular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Cellular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Cellular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.