The quest for enlightenment has occupied mankind for millennia. And from the depictions we’ve seen—monks sitting on meditation cushions, nuns kneeling in prayer, shamans communing with the universe—it seems that this elusive state is reserved for a chosen few. But now, neuroscientist David Perlmutter and medical anthropologist and shaman Alberto Villoldo have come together to explore the commonalities between their specialties with the aim of making enlightenment possible for anyone. Joining the long-separated worlds of science and spirit, Perlmutter explores the exciting phenomena of neurogenesis and mitochondrial health, while Villoldo brings his vast knowledge of shamanic and spiritual practices to the table. Together they draw from the most powerful tools in each discipline to create the Power Up Your Brain program, a ground-breaking, five-week plan that helps prime the brain for enlightenment. With nutritional advice, dietary supplements, physical exercise, shamanic practices, meditation, and visualizations, Perlmutter and Villoldo guide readers, step by step, through a program to help them clear their minds from previous trauma and open themselves up to experience the inner peace, vast insight, and extraordinary creativity that define the experience of enlightenment, paving the way to successfully face the challenges to come.