Prevalence of Drug-Drug Interactions of Antiretroviral Agents in the Private Health Care Sector in South Africa.
Objectives. Human immunodeficiency virus (HIV) infection can be effectively treated with highly active antiretroviral therapy (HAART), requiring concomitant administration of three to four different agents, often with a high potential for drug-drug interactions (DDIs). This study aimed to determine the prevalence of possible DDIs between antiretrovirals (ARVs) themselves and other drugs. Design. Retrospective drug utilisation study using data from a national medicine claims database for the period 1 January to 31 December 2004.