Infection is the most common cause of death following burn injury. Burn patients are at a high risk for infection as a result of the nature of the burn injury itself, the immunocompromising effects of burns, prolonged hospital stays, and intensive diagnostic and therapeutic procedures (1). In addition, the control and prevention of infectious diseases among burned patients present a greater and more specialized problem, because the skin barriers are disrupted, the environment in burn units can become contaminated with resistant organisms, and these organisms can be transmitted easily from one patient to another. Thus, burn care units (BCU) can be the site of explosive and prolonged outbreaks caused by resistant organisms (2,3). Although eradication of infection in burn patients is impossible, a well conducted surveillance, infection control and prevention programme can help reduce the incidence. It is known that effective surveillance and infection control may reduce infection, mortality rates, length of hospitalization and associated costs. The objective of this prospective study was to identify the most common pathogens and their antibacterial patterns, the incidence of nosocomial infection (NI) related to invasive device usage in A Turkish BCU. Also the risk factors for acquisition of NI in burn patients were also assessed.