Relevance of Specific Immunoglobulin M and Immunoglobulin G for Parvovirus B19 Diagnosis in Patients with Acute Lymphoblastic Leukemia Receiving Chemotherapy: Prospective Study (Clinical Report)

Relevance of Specific Immunoglobulin M and Immunoglobulin G for Parvovirus B19 Diagnosis in Patients with Acute Lymphoblastic Leukemia Receiving Chemotherapy: Prospective Study (Clinical Report)

Parvovirus B19 (PB19) virion has a simple structure composed of only 2 proteins and a linear, single-stranded DNA molecule. The nonenveloped viral particles are 22 to 24 nm in diameter and show icosahedral symmetry, and often both empty and full capsids are visible by negative staining and electron microscopy. (1) Children are probably at highest risk of acquiring PB19 infection because they may not yet have encountered the infection and thus lack immunity. Parvovirus exhibits a marked tropism to human bone marrow, replicating exclusively in erythroid progenitor cells. (2)

Relevance of Specific Immunoglobulin M and Immunoglobulin G for Parvovirus B19 Diagnosis in Patients with Acute Lymphoblastic Leukemia Receiving Chemotherapy: Prospective Study (Clinical Report)

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