Serotonin Transporter Gene Polymorphisms & Obsessive-Compulsive Disorder (Commentary) (Report)

Serotonin Transporter Gene Polymorphisms & Obsessive-Compulsive Disorder (Commentary) (Report)

Obsessive compulsive disorder (OCD) is a neuropsychiatric condition that has been shown to be heritable and for which a major gene effect has been reported based on segregation studies (1,2). However, linkage analysis studies have not been able to confirm a locus for OCD (3). The most promising candidate genes for OCD at the present time are in the serotonin system and the glutamate system (4). The SCL6A4 gene has been the most extensively studied functional polymorphism in psychiatry, providing worldwide evidence of its importance in several disorders, such as OCD. The efficacy of selective serotonin reuptake inhibitors (SSRIs) in the treatment of OCD has lead to the hypothesis of a serotonergic dysfunction in this disorder (5). Since SSRIs acts on the serotonin (5HT) transporter (5HTT), it has been suggested that the 5HTT gene (SCL6A4), located on chromosome 17q12 (6), could be a good candidate for OCD (7-9). A functional polymorphism in the promoter region has been described (10). This 5HTT-linked polymorphic region (5HTTLPR) is situated in a GC-rich region composed of 20-23 bp repeat units. The biallelic polymorphism consists of an insertion (long allele, “l”) or a deletion (short allele, “s”) of 44 bp. The serotonin transporter (SERT) is probably the most widely studied gene in psychiatry11. Previous studies have reported the “l” allele is as characterized by increased transcriptional activity as well as increased basal re-uptake of 5-HT in vitro compared with the short form of the 5HTTLPR (10).

Serotonin Transporter Gene Polymorphisms & Obsessive-Compulsive Disorder (Commentary) (Report)



Here is Download Link

Gene Environment Interplay


Gene Environment Interplay Read Online Download

Author by :
Languange Used : en
Release Date : 2012-12-31
Publisher by : Academic Press






Promoter Polymorphism Of The Serotonin Transporter Gene Influences The Number Of Sexual Partners And Smoking Habits In A Mexican Mestizo Population


Promoter Polymorphism Of The Serotonin Transporter Gene Influences The Number Of Sexual Partners And Smoking Habits In A Mexican Mestizo Population Read Online Download

Author by :
Languange Used : en
Release Date : 2015
Publisher by :






Genes Polymorphisms And The Making Of Societies


Genes Polymorphisms And The Making Of Societies Read Online Download

Author by : Hippokratis Kiaris
Languange Used : en
Release Date : 2012
Publisher by : Universal-Publishers






Environmental Experience And Plasticity Of The Developing Brain


Environmental Experience And Plasticity Of The Developing Brain Read Online Download

Author by : Alessandro Sale
Languange Used : en
Release Date : 2016-02-04
Publisher by : John Wiley & Sons






Psychiatric Pharmacogenomics


Psychiatric Pharmacogenomics Read Online Download

Author by : David Mrazek
Languange Used : en
Release Date : 2010-06-10
Publisher by : Oxford University Press






Serotonin Transporter 5 Httlpr And Norepinephrine Transporter Net Gene Polymorphisms Susceptibility And Treatment Response Of Electroconvulsive Therapy In Treatment Resistant Depression


Serotonin Transporter 5 Httlpr And Norepinephrine Transporter Net Gene Polymorphisms Susceptibility And Treatment Response Of Electroconvulsive Therapy In Treatment Resistant Depression Read Online Download

Author by :
Languange Used : en
Release Date : 2015
Publisher by :






Pharmacogenomics In Psychiatry


Pharmacogenomics In Psychiatry Read Online Download

Author by : M. Schwab
Languange Used : en
Release Date : 2010-06-25
Publisher by : Karger Medical and Scientific Publishers






Pharmacogenomics In Psychiatry


Pharmacogenomics In Psychiatry Read Online Download

Author by : Matthias Schwab
Languange Used : en
Release Date : 2010-01-01
Publisher by : Karger Medical and Scientific Publishers






Fundamental Neuroscience


Fundamental Neuroscience Read Online Download

Author by : Larry Squire
Languange Used : en
Release Date : 2002-11-19
Publisher by : Elsevier






Biology Of Personality Disorders


Biology Of Personality Disorders Read Online Download

Author by : Kenneth R. Silk
Languange Used : en
Release Date : 1998
Publisher by : American Psychiatric Pub






Leave a Reply

Your email address will not be published. Required fields are marked *