Spinal Cord Stimulation As a Method of Reducing Opioids in Severe Chronic Pain: A Case Report and Review of the Literature (Scientific Article: Special Issue) (Case Study)

Spinal Cord Stimulation As a Method of Reducing Opioids in Severe Chronic Pain: A Case Report and Review of the Literature (Scientific Article: Special Issue) (Case Study)

Introduction Spinal Cord Stimulation (SCS) was first described in the literature in 1967, when it was used by Shealy to treat pain secondary to invasive cancer involving the thoracic nerve roots. (1) Shortly after this initial report, the Food and Drug Administration (FDA) approved the use of SCS for neuropathic pain of the trunk and […]

American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer (Special Article)

American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer (Special Article)

INTRODUCTION In 2008, the American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) decided to pursue an investigation of whether a guideline for estrogen receptor (ER) and progesterone receptor (PgR) testing would be necessary and beneficial for patients with breast cancer. The two organizations had published a joint guideline on human […]

Recommendations for Validating Estrogen and Progesterone Receptor Immunohistochemistry Assays (Original Article)

Recommendations for Validating Estrogen and Progesterone Receptor Immunohistochemistry Assays (Original Article)

Validation of a clinical laboratory test means confirmation, through a defined process, that the test performs as intended or claimed. Proper validation provides reasonable, but not absolute, assurance that a test is performing as anticipated. There is no single, universally acceptable procedure for validating clinical laboratory tests. The design of a validation protocol requires professional […]

Systemic Mastocytosis: A Concise Clinical and Laboratory Review (Review Article) (Report)

Systemic Mastocytosis: A Concise Clinical and Laboratory Review (Review Article) (Report)

The discovery of mast cells (MCs) in 1878 is credited to Paul Ehrlich, who first described cells that stained with metachromatic dyes such as toluidine blue, which he termed MCs. Since then, extensive work has been done on the physiology, pathology, and genetics of normal MCs and their pathologic counterparts in mast cell disease (MCD). […]

Tissue Handling and Specimen Preparation in Surgical Pathology: Issues Concerning the Recovery of Nucleic Acids from Formalin-Fixed, Paraffin-Embedded Tissue (Review Article)

Tissue Handling and Specimen Preparation in Surgical Pathology: Issues Concerning the Recovery of Nucleic Acids from Formalin-Fixed, Paraffin-Embedded Tissue (Review Article)

Nucleic acid–based diagnostics are of great utility in molecular medicine but have been slower to reach the clinic than had been anticipated. The success of these platforms as biomarkers of disease is dependent on their reduction to an assay that is reproducible and widely applicable. (1,2) One hurdle in the introduction of nucleic acid-based diagnostics […]

Adverse Effect Management for Vascular Endothelial Growth Factor-Targeted Agents (Feature Article) (Clinical Report)

Adverse Effect Management for Vascular Endothelial Growth Factor-Targeted Agents (Feature Article) (Clinical Report)

Introduction In the 1960s, Dr Judah Folkman observed that tumours could not grow larger than the head of a pin in the absence of blood vessels. He first published his hypothesis that all malignant tumour growth is angiogenesis dependent, introducing the concept of ‘anti-angiogenesis’ as a potential novel anti-cancer therapy [1]. In 2003, the first […]

Resident Preparation for Practice: A White Paper from the College of American Pathologists and Association of Pathology Chairs (Special Article) (Report)

Resident Preparation for Practice: A White Paper from the College of American Pathologists and Association of Pathology Chairs (Special Article) (Report)

EXECUTIVE SUMMARY Pathology’s future depends on training pathologists who are as facile with new technologies as they are with the microscope. Trainees must absorb, assimilate, and be ready to apply an unprecedented breadth of scientific and technologic knowledge and concepts and apply these skills as part of the patient treatment team. During the past decade, […]