Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the Iedea Southern Africa Collaboration (Original Articles) (Report)

Monitoring the South African National Antiretroviral Treatment Programme, 2003-2007: the Iedea Southern Africa Collaboration (Original Articles) (Report)

The World Health Organization (WHO) estimated that in 2007, 9.7 million people in low–and middle-income countries needed antiretroviral treatment (ART), (1) 9% of whom were living in South Africa. (2) By the end of 2007, the South African National Department of Health (DoH) reported that 371 731 people had initiated highly active antiretroviral therapy (HAART), […]

Abdominal and Pericardial Ultrasound in Suspected Extrapulmonary Or Disseminated Tuberculosis (Original Articles) (Report)

Abdominal and Pericardial Ultrasound in Suspected Extrapulmonary Or Disseminated Tuberculosis (Original Articles) (Report)

Extrapulmonary tuberculosis (EPTB) is defined as tuberculosis (TB) of organs other than the lungs and usually results from lympho-haematogenous dissemination of the organism. The term disseminated TB refers to TB that involves multiple body systems, including the lungs. Target areas are usually those with high vascularity and include the lymph nodes, meninges, spleen, kidneys, spine […]

Risks for Preterm Delivery and Low Birth Weight are Independently Increased by Severity of Maternal Anaemia (Original Articles) (Report)

Risks for Preterm Delivery and Low Birth Weight are Independently Increased by Severity of Maternal Anaemia (Original Articles) (Report)

Anaemia is the most widespread nutritional disorder in the world, affecting 30% of the global population, and is even more prevalent among pregnant women. Massawe et al. showed that 65% of pregnant women attending antenatal clinics in Dar es Salaam were anaemic; (1) this constitutes a public health problem that requires attention. Anaemia has a […]

A Pivotal Role for Pneumolysin in the Immunopathogenesis, Treatment and Prevention of Pneumococcal Disease (Original Articles)

A Pivotal Role for Pneumolysin in the Immunopathogenesis, Treatment and Prevention of Pneumococcal Disease (Original Articles)

The pneumococcus remains an extremely important cause of morbidity and mortality worldwide. While the microorganism has a number of significant virulence mechanisms, many recent studies have focused on pneumolysin, which is recognised to be one of the most important virulence factors of the organism. The purpose of this manuscript is to review recent developments with […]

Mental Health Service Use Among South Africans for Mood, Anxiety and Substance Use Disorders (Original Articles) (Survey)

Mental Health Service Use Among South Africans for Mood, Anxiety and Substance Use Disorders (Original Articles) (Survey)

Of the national burden of disease, neuropsychiatric disorders are third only to HIV/AIDS and infectious disease, according to revised DALY (disability-adjusted life-years) estimates for the year 2000. (1,2) Yet mental health services are grossly under-resourced and there are many barriers to health care for the mentally ill. (3,4) Barriers include lack of accessibility, acceptability and […]

Acute Renal Failure in Four Comrades Marathon Runners Ingesting the Same Electrolyte Supplement: Coincidence Or Causation?(Original Articles) (Report)

Acute Renal Failure in Four Comrades Marathon Runners Ingesting the Same Electrolyte Supplement: Coincidence Or Causation?(Original Articles) (Report)

The 89 km Comrades Marathon historically reports the highest incidence of acute renal failure (ARF) cases in any sporting event in the world (estimated at 2/10 000 runners). (1) The first 2 cases reported from the event (in 1967 and 1968) occurred in races with only ~600 runners. (2) An incidence as high as 10/10 […]

Perpetration of Gross Human Rights Violations in South Africa: Association with Psychiatric Disorders (Original Articles) (Report)

Perpetration of Gross Human Rights Violations in South Africa: Association with Psychiatric Disorders (Original Articles) (Report)

South Africa provides a unique laboratory for studying the perpetration of different forms of violence. During apartheid a range of acts of racial violence were perpetrated, including gross human rights violations (HRVs). However, both before and after apartheid there have also been significant levels of domestic and criminal violence. (1) Injuries were the second-leading cause […]