Human immunodeficiency virus (HIV) infection is associated with cytopenias of all major blood cell lines. Anaemia occurs in up to 70% of patients with HIV/AIDS, and thrombocytopenia, neutropenia or lymphopenia in 40 – 70%. (1) The incidence and severity of cytopenias correlate directly with the degree of immunosuppression, while isolated haematological abnormalities, particularly anaemia and […]
Eastern Cape Province, with a population of 6.4 million, incorporates the former homelands of Transkei and Ciskei. (1) Mthatha (previously Umtata), the former capital of the Transkei, is one of the most economically depressed parts of South Africa. (1) Before 1994, public-funded primary care consisted of rural community clinics and health centres, with basic facilities […]
Asthma is the eighth leading contributor to the burden of disease in South Africa and is the second most important chronic disease after HIV/AIDS. (1) Asthma is often not considered particularly serious, but it causes significant morbidity in young and working-age adults that adds to the number of disability-adjusted life years (DALYs) in relation to […]
Joanne Corrigall, David Coetzee, Neil Cameron Objective. To determine the routine immunisation coverage rates in children aged 12-23 months in the Western Cape.
South Africa has a well-established system for vital registration and collection of mortality statistics, but is challenged by under-reporting of death statistics, particularly in rural areas and of young children. (1) The quality of medical certification and misclassification of causes of death are also of concern. (2-5) Errors could result from difficulties in clinical diagnosis, […]
Background and objectives. Patients with multidrug-resistant (MDR) tuberculosis (TB) are at high risk of treatment failure. It is anticipated that early identification of MDR-TB and appropriate treatment will improve patient outcome and disease control. We evaluated the rapid detection of rifampicin resistance in previously treated TB patients, directly from acid-fast bacilli (AFB)-positive sputum using a […]
Helicobacter pylori is the principal species of the genus Helicobacter that inhabits the gastric mucosa of the human stomach. It chronically infects billions of people worldwide, (1-3) and is responsible for one of the most frequent chronic bacterial infections involving more than 50% of the world’s population. (4) H. pylori is one of the most […]