Circulating Tumor Cells in Melanoma: A Review of the Literature and Description of a Novel Technique.

Circulating Tumor Cells in Melanoma: A Review of the Literature and Description of a Novel Technique.

Melanoma is a prevalent and deadly disease with limited therapeutic options. Current prognostic factors are unable to adequately guide treatment. Circulating tumor cells are a disease-specific factor that can be used as a prognostic variable to guide therapy. Most research to date has focused on identification of circulating tumor cells using various methods, including polymerase […]

Circulating Tumor Cells in Patients Undergoing Surgery for Hepatic Metastases from Colorectal Cancer (Clinical Report)

Circulating Tumor Cells in Patients Undergoing Surgery for Hepatic Metastases from Colorectal Cancer (Clinical Report)

The liver is often the only site of metastatic disease in patients with colorectal cancer, and such patients are considered for local therapies such as liver resection or tumor ablation. The 5-year survival rate for surgically treated patients is approximately 30% (1). Disease recurrence may be related to intraoperative factors such as the shedding of […]

Validation of the Circulating Monocyte Being Representative of the Cholesterol-Loaded Macrophage: Biomediator Activity.

Validation of the Circulating Monocyte Being Representative of the Cholesterol-Loaded Macrophage: Biomediator Activity.

Many data support the concept that atherosclerosis is an inflammatory process. (1,2) The earliest event in atherogenesis appears to be endothelial cell dysfunction. Various noxious insults including hypertension, diabetes, smoking, dyslipidemia, and hyperhomocystinemia can result in endothelial cell dysfunction. After endothelial cell dysfunction, mononuclear cells, such as monocytes (MOs) and T lymphocytes, initially loosely attach […]

Circulating Tumor Cells: Seeing Is Believing (Report)

Circulating Tumor Cells: Seeing Is Believing (Report)

Pathologists play an essential role in predicting which patients with cancer are likely to develop metastases. Therapies to treat or prevent metastases are currently based on tumor type, tumor grade, tumor stage, and a few immunohistochemical and molecular findings. Most of this information comes from the primary tumor. Early-stage tumors are composed of billions of […]

Pitfalls in the Measurement of Circulating Vascular Endothelial Growth Factor (Minireview)

Pitfalls in the Measurement of Circulating Vascular Endothelial Growth Factor (Minireview)

Vascular endothelial growth factor (VEGF)[1] is a specific mitogen and survival factor for endothelial cells and a key promoter of angiogenesis in physiological and pathophysiological conditions (1, 2). VEGF is required for the normal development of embryonic vasculature, the cyclic growth of blood vessels in the female reproductive tract, and the formation of capillaries during […]