Number of Lymph Nodes Examined and Associated Clinicopathologic Factors in Colorectal Carcinoma (Report)

Number of Lymph Nodes Examined and Associated Clinicopathologic Factors in Colorectal Carcinoma (Report)

Colorectal carcinoma is the second most common cause of cancer deaths in the United States. (1) The most important prognostic factor in colorectal carcinoma is the nodal status at the time of surgical treatment. The 5-year survival rate for stages I and II colorectal carcinomas is greater than 75%. With nodal metastasis, the 5-year survival […]

Clinicopathologic Characteristics, Cpg Island Methylator Phenotype, And BRAF Mutations in Microsatellite-Stable Colorectal Cancers Without Chromosomal Instability (Report)

Clinicopathologic Characteristics, Cpg Island Methylator Phenotype, And BRAF Mutations in Microsatellite-Stable Colorectal Cancers Without Chromosomal Instability (Report)

Colorectal cancer is characterized by a multistep progression of genetic errors that lead to derangement of epithelial growth and differentiation. (1) Two apparently distinct pathways of genomic instability have been implicated in carcinogenesis. Microsatellite instability plays a role in colorectal carcinomas arising in the setting of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and in 10% to […]