The liver is often the only site of metastatic disease in patients with colorectal cancer, and such patients are considered for local therapies such as liver resection or tumor ablation. The 5-year survival rate for surgically treated patients is approximately 30% (1). Disease recurrence may be related to intraoperative factors such as the shedding of […]
Each year in the USA, approximately 200,000 people are diagnosed with primary colorectal cancer; 75,000 patients with colorectal cancer do not survive, and half of those who survive develop tumor recurrence. Sixty percent of recurrences are found in the liver, 10% of which will be resectable. Patients at high risk of developing metastases from colorectal […]
Patterns of Care in Metastatic Colorectal Cancer is a unique continuing medical education activity that presents findings from a national survey of 101 general oncologists and the video recorded perspectives of clinical investigators Drs Johanna C Bendell and Alan P Venook on their approaches to key management challenges in metastatic colorectal cancer.
Colorectal carcinoma is the second most common cause of cancer deaths in the United States. (1) The most important prognostic factor in colorectal carcinoma is the nodal status at the time of surgical treatment. The 5-year survival rate for stages I and II colorectal carcinomas is greater than 75%. With nodal metastasis, the 5-year survival […]
This issue of Hematology/Oncology Clinics of North America, devoted to Colorectal Cancer, is edited by Dr. Leonard B. Saltz. Articles in this issue include: Diet and Lifestyle Influences on Colorectal Cancer; Diagnosis and Management of Germline and Somatic Mutations in Mismatch Repair-deficient Colorectal Cancer; Adjuvant Chemotherapy in Stage II, III, and Resected Stage IV Colon […]
In the United States, cancer of the colon and rectum has the unfortunate designation as the second leading cause of cancer death. (1) The principal treatment modality consists of surgical resection of the colon or rectum including the pericolonic fatty tissue. Lymph node (LN) retrieval from the pericolonic fatty tissue is necessary for proper tumor […]
Colorectal cancer is characterized by a multistep progression of genetic errors that lead to derangement of epithelial growth and differentiation. (1) Two apparently distinct pathways of genomic instability have been implicated in carcinogenesis. Microsatellite instability plays a role in colorectal carcinomas arising in the setting of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and in 10% to […]