Novel Peri-Vascular Drug Delivery for the Treatment of Neointimal Hyperplasia Associated with Ptfe Dialysis Graft Failure

Novel Peri-Vascular Drug Delivery for the Treatment of Neointimal Hyperplasia Associated with Ptfe Dialysis Graft Failure

Intimal hyperplasia (IH), that leads to hemodialysis access dysfunction, is a major problem affecting patients undergoing renal dialysis. This work aimed at developing a novel approach that entails peri-vascular delivery of cytotoxic agents such as paclitaxel for the inhibition of IH. We formulated a polymeric delivery system for use as a peri-vascular wrap around the […]

The Truth About the Drug Companies

The Truth About the Drug Companies

During her two decades at The New England Journal of Medicine, Dr. Marcia Angell had a front-row seat on the appalling spectacle of the pharmaceutical industry. She watched drug companies stray from their original mission of discovering and manufacturing useful drugs and instead become vast marketing machines with unprecedented control over their own fortunes. She […]

Drug Muggers

Drug Muggers

Unpleasant, uncomfortable, and unexplained side effects? Drug Muggers is your side effect solution. Prescription and over-the-counter drugs help millions of people with devastat-ing diseases and chronic conditions. But in the process, these medications can also deplete the body’s natural stores of vitamins, minerals, and hormones—the very nutrients you need to keep energy levels high, fend […]

Food: The Good Girl's Drug

Food: The Good Girl’s Drug

Bingeing, compulsive eating, food addiction, emotional overeating—no matter what you call it, too many women wrestle day to day with what they eat. It’s a love-hate relationship that always seems to be spiraling out of control. Food: The Good Girl’s Drug is one recovered binge eater’s attempt to inject some sanity back into the discussion […]

Ximelagatran (Exanta): Alternative to Warfarin?(Pharmacology Notes) (Drug Overview)

Ximelagatran (Exanta): Alternative to Warfarin?(Pharmacology Notes) (Drug Overview)

For decades, the standards of antithrombotic therapy have been heparin and coumarin compounds, primarily warfarin (1). Other newer approaches include low-molecular-weight heparins, fondaparinux, lepirudin, argatroban, and melagatran (investigational). Although existing treatments are effective, they have many limitations. A safer, more convenient therapy is needed. Ximelagatran is the first oral treatment in a new World Health […]

Darbepoetin Alfa (Aranesp) (Pharmacology Notes) (Drug Overview)

Darbepoetin Alfa (Aranesp) (Pharmacology Notes) (Drug Overview)

The Food and Drug Administration (FDA) approved darbepoetin alfa (Aranesp) for treatment of anemia as sociated with chronic renal failure (CRF) in patients on dialysis and patients not on dialysis (1). The manufacturer of the drug also filed an application with the FDA on September 18, 2001, to receive an indication for treatment of anemia […]

Emergence of Extensive Drug Resistance (XDR) Among Gramnegative Bacilli in South Africa Looms Nearer (Issues IN PUBLIC Health) (Report)

Emergence of Extensive Drug Resistance (XDR) Among Gramnegative Bacilli in South Africa Looms Nearer (Issues IN PUBLIC Health) (Report)

Until recently, the term ‘extensive drug resistance’ (XDR) was held to be applicable to Mycobacterium tuberculosis only. It is now clear that Gram-negative bacilli are moving a step closer towards acquiring similar resistance. The emergence of multi(MDR) and pan-drug resistant (PDR) Gram-negative health care-associated pathogens has been confined to non-fermenters such as Pseudomonas aeruginosa and […]