Polymorphisms in Tgf[Beta] and Tnf[Alpha] are Associated with the Myelodysplastic Syndrome Phenotype (Transforming Growth Factor) (Tumor Necrosis Factor) (Report)

Polymorphisms in Tgf[Beta] and Tnf[Alpha] are Associated with the Myelodysplastic Syndrome Phenotype (Transforming Growth Factor) (Tumor Necrosis Factor) (Report)

The myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, multilineage dysplasia, peripheral cytopenias, and susceptibility to leukemia. (1) Demonstrating a varied spectrum of biologic, genetic, morphologic, and clinical characteristics, MDS has a natural history ranging from enduring years of indolent disease to an accelerated progression toward […]

Activated Protein C Resistance and Factor V Leiden: A Review (Report)

Activated Protein C Resistance and Factor V Leiden: A Review (Report)

Factor V Leiden (FVL) describes a G1691A nucleotide transition resulting in an R506Q amino acid missense mutation. Early papers showed that the resulting factor V protein was resistant to proteolysis by activated protein C (APC), and it is now recognized that FVL accounts for 90% to 95% of cases of APC resistance. Factor V resistance […]

HER2 Testing: State of the Laboratories (Human Epidermal Growth Factor Receptor 2) (Editorial)

HER2 Testing: State of the Laboratories (Human Epidermal Growth Factor Receptor 2) (Editorial)

It has been more than 2 decades since the first publication describing the potential role of HER2 in breast cancer. A variety of techniques were employed in the initial studies to assess HER2 at DNA, RNA, and protein levels. These studies, mostly retrospective, demonstrated that HER2 is a marker of poor prognosis and suggested that […]

Laboratory Compliance with the American Society of Clinical Oncology/College of American Pathologists Guidelines for Human Epidermal Growth Factor Receptor 2 Testing: A College of American Pathologists Survey of 757 Laboratories (Cap Laboratory Improvement Programs)

Laboratory Compliance with the American Society of Clinical Oncology/College of American Pathologists Guidelines for Human Epidermal Growth Factor Receptor 2 Testing: A College of American Pathologists Survey of 757 Laboratories (Cap Laboratory Improvement Programs)

Human epidermal growth receptor 2 gene ERBB2 (commonly referred to as HER2) amplification status is an important prognostic marker in breast cancer and is a factor in determining patient therapy. (1-5) The American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) introduced guidelines for HER2 testing in December 2006, which were […]

Pitfalls in the Measurement of Circulating Vascular Endothelial Growth Factor (Minireview)

Pitfalls in the Measurement of Circulating Vascular Endothelial Growth Factor (Minireview)

Vascular endothelial growth factor (VEGF)[1] is a specific mitogen and survival factor for endothelial cells and a key promoter of angiogenesis in physiological and pathophysiological conditions (1, 2). VEGF is required for the normal development of embryonic vasculature, the cyclic growth of blood vessels in the female reproductive tract, and the formation of capillaries during […]

The Enzyme Factor

The Enzyme Factor

As our national medical system faces serious breakdowns Hiromi Shinya MD  points the way to a new vision for health care.His revolutionary research suggests we have a prototype enzyme that is the key to life and health. After 45 years as a practicing physician and examining over 300,000 people in the United States and Japan, […]

Factor V 1691 G-A Mutation Distribution in a Healthy Turkish Population/Saglikli Turk Populasyonunda Faktor V (1691 G-A) Mutasyon Sikligi (Report)

Factor V 1691 G-A Mutation Distribution in a Healthy Turkish Population/Saglikli Turk Populasyonunda Faktor V (1691 G-A) Mutasyon Sikligi (Report)

Factor V Leiden (1691 G-A) (FVL) causes activated protein C resistance and is the most common thrombophilic mutation worldwide. Guanine to adenine change leads to a replacement of glutamine to arginine at amino acid position 506. It is most prevalent among Caucasians but not found in Japanese and Africans [1,2]. Anatolia is at the crossroads […]