Hypertension is a complex disease involving interaction of many risk genes and environmental factors such as obesity, dietary salt intake, alcohol consumption, and stress. Approximately 20 to 60 per cent of the population variability in blood pressure is genetically determined (1). In the last decade, a large number of candidate genes have been tested for […]
Medical Genetics at a Glance covers the core scientific principles necessary for an understanding of medical genetics and its clinical applications, while also considering the social implications of genetic disorders. This third edition has been fully updated to include the latest developments in the field, covering the most common genetic anomalies, their diagnosis and management, […]
This year it is estimated that 30,000 Americans will be diagnosed with kidney cancer and 12,500 will die of the disease. Both the incidence rate and the mortality rate are increasing; because of the rapid rise, kidney cancer is on the National Cancer Institute’s (NCI’s) watch list. The increases cannot be explained by better detection […]
Introduction Uhl’s anomaly, arrhythmogenic right ventricular dysplasia / cardiomyopathy (ARVD/C) and right ventricular outflow tract ventricular tachycardia (RVOT VT) involve pathogenic changes in the right ventricular (RV) myocardium. Though complete pathogenic mechanisms have not been discovered for the three disorders, there is a speculation that these may be milder or severe manifestations of the same […]
The only official Kaplan Lecture Notes for USMLE Step 1 cover the comprehensive information you need to ace the exam and match into the residency of your choice. * Up-to-date: Updated annually by Kaplan’s all-star faculty * Integrated: Packed with clinical correlations and bridges between disciplines * Learner-efficient: Organized in outline format with high-yield summary […]
This handbook provides accessible information on specific genetic diseases, and possible genetic components of major diseases, for the primary health care team and junior doctor in training. It assists with why, when, and where to refer patients, and affected families, to get the best advice about genetic disease.
Ever since the International Human Genome Project achieved its extraordinary goal of sequencing and mapping the entire human genome, represented by approximately 3 billion base pairs, with its far-reaching implications for understanding the causes of human genetic disorders and their diagnosis, progress in the field has not slowed down. In the fifth edition of the […]