Pharmacovigilance in Kala-Azar Patients with Severe Thrombocytopenia Caused by Sodium Antimony Gluconate & Miltefosine.

Pharmacovigilance in Kala-Azar Patients with Severe Thrombocytopenia Caused by Sodium Antimony Gluconate & Miltefosine.

Sodium antimony gluconate (SAG) and miltefosine used in the treatment of kala-azar are known to cause several side effects but severe thrombocytopenia has not been reported. Four cases of severe thrombocytopenia, two caused by SAG and two by miltefosine were promptly detected and treated by immediate withdrawal of the offending drugs, platelet and blood transfusions […]