Pharmacovigilance in Kala-Azar Patients with Severe Thrombocytopenia Caused by Sodium Antimony Gluconate & Miltefosine.

Pharmacovigilance in Kala-Azar Patients with Severe Thrombocytopenia Caused by Sodium Antimony Gluconate & Miltefosine.

Sodium antimony gluconate (SAG) and miltefosine used in the treatment of kala-azar are known to cause several side effects but severe thrombocytopenia has not been reported. Four cases of severe thrombocytopenia, two caused by SAG and two by miltefosine were promptly detected and treated by immediate withdrawal of the offending drugs, platelet and blood transfusions […]

Newer Strategies for the Kala-Azar Elimination Programme in India (Correspondence) (Report)

Newer Strategies for the Kala-Azar Elimination Programme in India (Correspondence) (Report)

Sir, Three attempts made in independent India to eliminate kala-azar (visceral leishmaniasis) have failed. The massive DDT spray programme under National Malaria Control Programme (1953-68) resulted in cases of post kala-azar dermal leishmaniasis (PKDL) (1) and chronic kala-azar cases from rural area (2) that were ignored. A 6-10 day course of 6 ml intramuscular injection […]