Comparison of MGIT 960 & Pyrazinamidase Activity Assay for Pyrazinamide Susceptibility Testing of Mycobacterium Tuberculosis (Report)

Comparison of MGIT 960 & Pyrazinamidase Activity Assay for Pyrazinamide Susceptibility Testing of Mycobacterium Tuberculosis (Report)

Pyrazinamide (PZA) is an important front line drug used in conjunction with isoniazid and rifampicin in short course chemotherapy to treat tuberculosis. It is a synthetic pyrazine analogue of nicotinamide and a prodrug, which is converted to the active form pyrazinoic acid by an enzyme pyrazinamidase (PZase) (1). Rapid detection of drug susceptibility profile of […]