Clinicopathologic Characteristics, Cpg Island Methylator Phenotype, And BRAF Mutations in Microsatellite-Stable Colorectal Cancers Without Chromosomal Instability (Report)

Clinicopathologic Characteristics, Cpg Island Methylator Phenotype, And BRAF Mutations in Microsatellite-Stable Colorectal Cancers Without Chromosomal Instability (Report)

Colorectal cancer is characterized by a multistep progression of genetic errors that lead to derangement of epithelial growth and differentiation. (1) Two apparently distinct pathways of genomic instability have been implicated in carcinogenesis. Microsatellite instability plays a role in colorectal carcinomas arising in the setting of Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and in 10% to […]