Of Rain Men and Snowcakes: The Presentation, Pathology, Aetiology and Management of Autistic Spectrum Disorder (Disease/Disorder Overview)

Of Rain Men and Snowcakes: The Presentation, Pathology, Aetiology and Management of Autistic Spectrum Disorder (Disease/Disorder Overview)

Over the past 20 years, research into the causes of autism has expanded due to technological advances in basic and medical science. The portrayal of autistic individuals by the entertainment media in films such as ‘Rain Man’ and, most recently ‘Snowcake’, as well as the publicity surrounding the suggested role of vaccines in the causation […]

Nontuberculous Mycobacterial Infections (Disease/Disorder Overview) (Clinical Report)

Nontuberculous Mycobacterial Infections (Disease/Disorder Overview) (Clinical Report)

Nontuberculous mycobacteria (NTM) comprise a variety of species and are responsible for a wide range of clinical syndromes. They encompass all mycobacterial species other than Mycobacterium tuberculosis complex (MTB) and Mycobacterium leprae. Nontuberculous mycobacteria have been known since the time of Robert Koch, but historically they have been overshadowed by tuberculosis and dismissed as contaminants. […]

How Much Tissue Sampling Is Required when Unsuspected Minimal Prostate Carcinoma Is Identified on Transurethral Resection?(Disease/Disorder Overview)

How Much Tissue Sampling Is Required when Unsuspected Minimal Prostate Carcinoma Is Identified on Transurethral Resection?(Disease/Disorder Overview)

Transurethral resection of the prostate (TURP) is still a common urologic procedure that is primarily used in current practice for the surgical management of benign prostatic hyperplasia. The quantity of tissue chips received in the pathology laboratory for examination varies. Recommendations by the College of American Pathologists (CAP) require submission of specimens weighing 12 g […]

A Unique Case of Mantle Cell Lymphoma with an Aberrant [Cd5.Sup.-]/[Cd10.Sup.+] Immunophenotype and Typical Morphology (Disease/Disorder Overview)

A Unique Case of Mantle Cell Lymphoma with an Aberrant [Cd5.Sup.-]/[Cd10.Sup.+] Immunophenotype and Typical Morphology (Disease/Disorder Overview)

Mantle cell lymphoma (MCL) is a moderately aggressive B-cell non-Hodgkin lymphoma (NHL) that was first distinguished in the 1990s from morphologically similar lymphomas, such as small lymphocytic lymphoma (SLL) and follicular lymphoma (FL). Its characteristic immunophenotype includes coexpression of B-cell markers, CD5, and FMC-7 and absence of CD23, whereas the translocation t(11;14)(q13;q32) confirms the diagnosis. […]

Poorly Differentiated Gastroenteropancreatic Neuroendocrine Carcinoma Associated with X-Linked Hyperimmunoglobulin M Syndrome (Case Report) (Disease/Disorder Overview)

Poorly Differentiated Gastroenteropancreatic Neuroendocrine Carcinoma Associated with X-Linked Hyperimmunoglobulin M Syndrome (Case Report) (Disease/Disorder Overview)

Neuroendocrine tumors (NETs) arise from the cells of the disseminated neuroendocrine system, which is widely distributed in the body. These are a rare and heterogeneous group of neoplasms characterized by differences in embryologic, biologic, and histopathologic aspects. (1) Gastroenteropancreatic NETs constitute about 2% to 3% of all gastrointestinal malignancies. In 2000, a new World Health […]

Hyperhomocysteinemia and Thrombosis: An Overview (Report)

Hyperhomocysteinemia and Thrombosis: An Overview (Report)

Homocysteine is a sulfur-containing amino acid absent in naturally occurring dietary sources. It is closely related to the essential amino acid methionine and to cysteine. Butz and Du Vigneaud (1) described the formation of homocystine from treating methionine with concentrated acid. Homocysteine is a metabolic intermediary in transmethylation and transsulfuration reactions. S-Adenosylmethionine (SAM), an intermediary […]