Drotrecogin Alfa (Activated): The First Fda-Approved Treatment for Severe Sepsis (Pharmacology Notes) (Drug Overview)

Drotrecogin Alfa (Activated): The First Fda-Approved Treatment for Severe Sepsis (Pharmacology Notes) (Drug Overview)

Drotrecogin alfa (activated) (Xigris, Eli Lilly and Company, Indianapolis, Ind) is a recombinant form of human activated protein C. It was approved by the Food and Drug Administration in the last quarter of 2001 for the reduction of mortality due to severe sepsis in adult patients who are at high risk of death (1). This […]

Leuconostoc Spp Sepsis in an Extremely Low Birth Weight Infant: A Case Report and Review of the Literature (Scientific Article) (Clinical Report)

Leuconostoc Spp Sepsis in an Extremely Low Birth Weight Infant: A Case Report and Review of the Literature (Scientific Article) (Clinical Report)

Introduction Leuconostoc spp are gram-positive cocci known to be present in plant, milk, dairy products and wine (1). It was not until the 1980s that these organisms were noted to have association with human and animal diseases. In 1984, Coleman and Ball reported the isolation of Leuconostoc spp from blood cultures (2). In 1985, Buu-Hui […]

Elevated Cardiac Troponins in Sepsis: What Do They Signify?(Scientific Article) (Report)

Elevated Cardiac Troponins in Sepsis: What Do They Signify?(Scientific Article) (Report)

Introduction Sepsis is a major source of morbidity and mortality in the United States with more than 750,000 patients diagnosed annually including more than 250,000 deaths (8). Sepsis has been defined as the presence of the systemic inflammatory response syndrome (SIRS) in response to a culture-proven infection. To meet SIRS criteria, two of the following […]

Evaluation of Microbiologic and Hematologic Parameters and E-Selectin As Early Predictors for Outcome of Neonatal Sepsis (Report)

Evaluation of Microbiologic and Hematologic Parameters and E-Selectin As Early Predictors for Outcome of Neonatal Sepsis (Report)

Morbidity and mortality from neonatal sepsis are major health problems. Early warning signs and symptoms are often nonspecific and can easily be confused with those from noninfective causes. Timely diagnosis of neonatal sepsis is critical because, in this age group, the illness can progress more rapidly and have a higher mortality rate than in other […]