Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease

Emerging Therapies Targeting the Pathophysiology of Sickle Cell Disease

This issue of Hematology/Oncology Clinics, guest edited by Dr. Elliott Vichinsky, is devoted to Sickle Cell Disease, and focuses on pathophysiology of hemoglobinopathies, therapeutic targets, and new approaches to correcting ineffective erythropoiesis and iron dysregulation. Articles in this issue include Polymerization and red cell membrane changes; Overview on reperfusion injury in the pathophysiology of SCD; […]

Immunohematological Characteristics of Nigerian Sickle Cell Disease Patients with Osteomyelitis/ Osteomiyeliti Olan Nijeryali Orak Hucre Hastaligina Sahip Kisilerin Immunohematolojik Ozellikleri (Research Article) (Report)

Immunohematological Characteristics of Nigerian Sickle Cell Disease Patients with Osteomyelitis/ Osteomiyeliti Olan Nijeryali Orak Hucre Hastaligina Sahip Kisilerin Immunohematolojik Ozellikleri (Research Article) (Report)

Introduction Bone involvement in the form of painful vaso-occlusive crisis, osteomyelitis, bone necrosis, chronic arthritis, and impaired growth are common manifestations of sickle cell disease (SCD) [1]. The microvascular circulation of the bones is a common site for sickled red cells to lodge, leading to thrombosis, infarction, and necrosis of the bone [2,3]. Infarcted bones […]