Mycobacterium tuberculosis, the aetiological agent of tuberculosis (TB), has re-emerged as a killer pathogen in western countries after the increase of HIV-AIDS cases and development of resistance to various anti-tubercular drugs. This increase in the number of multi-drug resistant M. tuberculosis isolates has drawn the attention towards the identification of alternate drugs like fluoroquinolones (FQs) […]
Pyrazinamide (PZA) is an important front line drug used in conjunction with isoniazid and rifampicin in short course chemotherapy to treat tuberculosis. It is a synthetic pyrazine analogue of nicotinamide and a prodrug, which is converted to the active form pyrazinoic acid by an enzyme pyrazinamidase (PZase) (1). Rapid detection of drug susceptibility profile of […]
Byline: Afreenish Hassan, Javaid Usman, Fatima Kaleem, Maria Omair, Ali Khalid and Muhammad Iqbal ABSTRACT
Staphylococcus aureus is a Gram-positive bacterium frequently implicated in a variety of infectious processes ranging from relatively benign skin infections to life-threatening systemic illnesses. The organism possesses several properties that contribute to its ability to cause serious disease, including the production of toxins. Since S. aureus is a significant cause of nosocomial and community-acquired infections, […]
INTRODUCTION Resistant bacteria are emerging worldwide as a threat to favorable outcome in the treatment of common infections in community and hospital settings (1). Among the wide array of antibiotics, [beta]-lactams are the most widely used agents. The most common cause of resistance to [beta]-lactam antibiotics is the production of [beta]-lactamases. Emergence of resistance to […]
INTRODUCTION Bacterial infections at surgical sites and surgical wounds are fairly common despite aseptic measures. Surgical site infections are responsible for delayed wound healing, prolonged stay in hospital, increased cost of therapy and are also important determinants of morbidity and mortality of the patient.
Byline: Nadeem Sajjad Raja, David Parratt and Marilyn Meyers ABSTRACT