HIV/AIDS Influences Blood and Blood Product Use at Groote Schuur Hospital, Cape Town (Original Articles) (Report)

HIV/AIDS Influences Blood and Blood Product Use at Groote Schuur Hospital, Cape Town (Original Articles) (Report)

Human immunodeficiency virus (HIV) infection is associated with cytopenias of all major blood cell lines. Anaemia occurs in up to 70% of patients with HIV/AIDS, and thrombocytopenia, neutropenia or lymphopenia in 40 – 70%. (1) The incidence and severity of cytopenias correlate directly with the degree of immunosuppression, while isolated haematological abnormalities, particularly anaemia and […]

Quality of Cause of Death Certification at an Academic Hospital in Cape Town, South Africa (Original Articles) (Report)

Quality of Cause of Death Certification at an Academic Hospital in Cape Town, South Africa (Original Articles) (Report)

South Africa has a well-established system for vital registration and collection of mortality statistics, but is challenged by under-reporting of death statistics, particularly in rural areas and of young children. (1) The quality of medical certification and misclassification of causes of death are also of concern. (2-5) Errors could result from difficulties in clinical diagnosis, […]

Utilisation and Outcomes of Cervical Cancer Prevention Services Among Hiv-Infected Women in Cape Town (Original Articles) (Report)

Utilisation and Outcomes of Cervical Cancer Prevention Services Among Hiv-Infected Women in Cape Town (Original Articles) (Report)

Cervical cancer is the most common cancer among South African women. The age-standardised mortality rate from cervical cancer is 21.0% in South Africa but only 8.9% worldwide. (1,2) This differential highlights inequality in the availability of screening for easily treated precursor lesions. South Africa’s cervical cancer burden severity is compounded by its HIV epidemic (2008 […]

Negative Association of MC3R Variants with Weight and Blood Pressure in Cape Town Pupils Aged 11-16 Years (Original Articles) (Melanocortin 4 Receptor Gene) (Report)

Negative Association of MC3R Variants with Weight and Blood Pressure in Cape Town Pupils Aged 11-16 Years (Original Articles) (Melanocortin 4 Receptor Gene) (Report)

Obesity is a multifactorial body weight abnormality resulting from genetic and environmental interactions. Of the body mass index (BMI) variation among obese individuals of different populations and within the same family, 40-70% are estimated to be inherited, and 30% are attributed to cultural and socio-economic factors. (1,2) More than 100 genes have been implicated in […]