Prolonged Deferral of Antiretroviral Therapy in the SAPIT Trial: Did We Need a Clinical Trial to Tell Us That This Would Increase Mortality?(Issues IN Research) (Clinical Report)

Prolonged Deferral of Antiretroviral Therapy in the SAPIT Trial: Did We Need a Clinical Trial to Tell Us That This Would Increase Mortality?(Issues IN Research) (Clinical Report)

Tuberculosis is the major cause of morbidity and mortality in HIV-infected patients in sub-Saharan Africa. HIV infection is often first diagnosed following a diagnosis of tuberculosis, with many patients needing antiretroviral therapy (ART). Starting ART in HIV-infected patients with tuberculosis (TB) may be associated with complications, including side-effects from co-administration of multiple drugs with many […]

Adolescent Experiences in a Vaccine Trial: A Pilot Study (Original Articles) (Report)

Adolescent Experiences in a Vaccine Trial: A Pilot Study (Original Articles) (Report)

Healthcare workers often practise dose extrapolation when prescribing medicines for children ( 18 years) owing to lack of data for this group. (1) Incentives and legislation aimed at addressing this gap (2) may increase the number of child-focused trials. However, there is little research on how this age group experiences clinical trials. (3) Methods

Fall and Balance Outcomes After an Intervention to Promote Leg Strength, Balance, And Walking in People with Diabetic Peripheral Neuropathy: "Feet First" Randomized Controlled Trial (Research Report) (Report)

Fall and Balance Outcomes After an Intervention to Promote Leg Strength, Balance, And Walking in People with Diabetic Peripheral Neuropathy: “Feet First” Randomized Controlled Trial (Research Report) (Report)

In patients with diabetes, regular participation in physical activity can improve glycemic control and reduce cardiovascular mortality. (1,2) Exercise that improves lower-extremity balance and strength (force-generating capacity) has been shown to be effective in reducing falls in older adults. (3-7) However, people who are sedentary and people with insensate feet (8) have an increased risk […]

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function After a Lifestyle Modification Trial Among Obese Children (Lipids, Lipoproteins, And Cardiovascular Risk Factors)

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function After a Lifestyle Modification Trial Among Obese Children (Lipids, Lipoproteins, And Cardiovascular Risk Factors)

The prevalence of childhood obesity and its consequences are increasing rapidly in low- and middle-income countries (1). It is well documented that childhood obesity tracks into adulthood. Of special concern are the cardiometabolic consequences of obesity, especially hypertension, dyslipidemia, and impaired glucose metabolism, that are already present in young children of different ethnicities (2, 3). […]