Payment of Trial Participants Can Be Ethically Sound: Moving Past a Flat Rate (Opinion)

Payment of Trial Participants Can Be Ethically Sound: Moving Past a Flat Rate (Opinion)

The South African Medicines Control Council (MCC) policy that trial participants be paid a flat rate of R150 per visit in clinical trials has been criticised in the press. (1) The literature argues that it is an excessive or inappropriate reward; (2) it neglects salient factors such as the design or nature of the study, […]

Multi-Center Surveillance for Pneumonia & Meningitis Among Children (2 Yr) for Hib Vaccine Probe Trial Preparation in India (Report)

Multi-Center Surveillance for Pneumonia & Meningitis Among Children (2 Yr) for Hib Vaccine Probe Trial Preparation in India (Report)

Introduction Haemophilus influenzae has long been recognised as a cause of serious infections (i.e., pneumonia and meningitis) and mortality in children less than 5 yr old. Prior to the introduction of H. influenzae type b (Hib) immunization, the incidence of invasive Hib infection was 20-50/100,000 children 5 yr of age in industrialized countries and higher […]

Prolonged Deferral of Antiretroviral Therapy in the SAPIT Trial: Did We Need a Clinical Trial to Tell Us That This Would Increase Mortality?(Issues IN Research) (Clinical Report)

Prolonged Deferral of Antiretroviral Therapy in the SAPIT Trial: Did We Need a Clinical Trial to Tell Us That This Would Increase Mortality?(Issues IN Research) (Clinical Report)

Tuberculosis is the major cause of morbidity and mortality in HIV-infected patients in sub-Saharan Africa. HIV infection is often first diagnosed following a diagnosis of tuberculosis, with many patients needing antiretroviral therapy (ART). Starting ART in HIV-infected patients with tuberculosis (TB) may be associated with complications, including side-effects from co-administration of multiple drugs with many […]

Adolescent Experiences in a Vaccine Trial: A Pilot Study (Original Articles) (Report)

Adolescent Experiences in a Vaccine Trial: A Pilot Study (Original Articles) (Report)

Healthcare workers often practise dose extrapolation when prescribing medicines for children ( 18 years) owing to lack of data for this group. (1) Incentives and legislation aimed at addressing this gap (2) may increase the number of child-focused trials. However, there is little research on how this age group experiences clinical trials. (3) Methods