Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function After a Lifestyle Modification Trial Among Obese Children (Lipids, Lipoproteins, And Cardiovascular Risk Factors)

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function After a Lifestyle Modification Trial Among Obese Children (Lipids, Lipoproteins, And Cardiovascular Risk Factors)

The prevalence of childhood obesity and its consequences are increasing rapidly in low- and middle-income countries (1). It is well documented that childhood obesity tracks into adulthood. Of special concern are the cardiometabolic consequences of obesity, especially hypertension, dyslipidemia, and impaired glucose metabolism, that are already present in young children of different ethnicities (2, 3). […]

A Randomized, Controlled Clinical Trial Comparing Efficacy, Safety and Cost Effectiveness of Lornoxicam with Diclofenac Sodium in Patients of Osteoarthritis Knee (Original Work) (Report)

A Randomized, Controlled Clinical Trial Comparing Efficacy, Safety and Cost Effectiveness of Lornoxicam with Diclofenac Sodium in Patients of Osteoarthritis Knee (Original Work) (Report)

INTRODUCTION Osteoarthritis is a chronic degenerative condition affecting joints including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness and locking of affected joint and sometimes joint cavity effusion. In majority, large joints of human body are affected more than smaller joints (1). Among these larger joints, knee joint is most commonly […]

Payment of Trial Participants Can Be Ethically Sound: Moving Past a Flat Rate (Opinion)

Payment of Trial Participants Can Be Ethically Sound: Moving Past a Flat Rate (Opinion)

The South African Medicines Control Council (MCC) policy that trial participants be paid a flat rate of R150 per visit in clinical trials has been criticised in the press. (1) The literature argues that it is an excessive or inappropriate reward; (2) it neglects salient factors such as the design or nature of the study, […]

Multi-Center Surveillance for Pneumonia & Meningitis Among Children (2 Yr) for Hib Vaccine Probe Trial Preparation in India (Report)

Multi-Center Surveillance for Pneumonia & Meningitis Among Children (2 Yr) for Hib Vaccine Probe Trial Preparation in India (Report)

Introduction Haemophilus influenzae has long been recognised as a cause of serious infections (i.e., pneumonia and meningitis) and mortality in children less than 5 yr old. Prior to the introduction of H. influenzae type b (Hib) immunization, the incidence of invasive Hib infection was 20-50/100,000 children 5 yr of age in industrialized countries and higher […]

Prolonged Deferral of Antiretroviral Therapy in the SAPIT Trial: Did We Need a Clinical Trial to Tell Us That This Would Increase Mortality?(Issues IN Research) (Clinical Report)

Prolonged Deferral of Antiretroviral Therapy in the SAPIT Trial: Did We Need a Clinical Trial to Tell Us That This Would Increase Mortality?(Issues IN Research) (Clinical Report)

Tuberculosis is the major cause of morbidity and mortality in HIV-infected patients in sub-Saharan Africa. HIV infection is often first diagnosed following a diagnosis of tuberculosis, with many patients needing antiretroviral therapy (ART). Starting ART in HIV-infected patients with tuberculosis (TB) may be associated with complications, including side-effects from co-administration of multiple drugs with many […]