Natural Reservoir, Zoonotic Tuberculosis & Interface with Human Tuberculosis: An Unsolved Question (Commentary) (Clinical Report)

Natural Reservoir, Zoonotic Tuberculosis & Interface with Human Tuberculosis: An Unsolved Question (Commentary) (Clinical Report)

Mycobacterium bovis is an important member of the M. tuberculosis complex. Although it is primarily recognized as an animal pathogen it can cause disease in humans too. Similarly, M. tuberculosis, though a human pathogen does infect animals. It is believed that as the human civilization has advanced through various stages of evolution it has acquired […]

Comparison of MGIT 960 & Pyrazinamidase Activity Assay for Pyrazinamide Susceptibility Testing of Mycobacterium Tuberculosis (Report)

Comparison of MGIT 960 & Pyrazinamidase Activity Assay for Pyrazinamide Susceptibility Testing of Mycobacterium Tuberculosis (Report)

Pyrazinamide (PZA) is an important front line drug used in conjunction with isoniazid and rifampicin in short course chemotherapy to treat tuberculosis. It is a synthetic pyrazine analogue of nicotinamide and a prodrug, which is converted to the active form pyrazinoic acid by an enzyme pyrazinamidase (PZase) (1). Rapid detection of drug susceptibility profile of […]

Potential for Nosocomial Transmission of Multidrug-Resistant (MDR) Tuberculosis in a South African Tertiary Hospital (Original Articles) (Report)

Potential for Nosocomial Transmission of Multidrug-Resistant (MDR) Tuberculosis in a South African Tertiary Hospital (Original Articles) (Report)

Tuberculosis (TB) is a major health problem in the Western Cape, with a rising incidence which now exceeds 900 per 100 000 population. (1) In this setting, nosocomial transmission of TB is a potential risk, particularly to HIV-infected or other immunocompromised patients. Nosocomial outbreaks of TB are usually noted initially because of increasing rates of […]

Diabetes & Tuberculosis: A Dangerous Liaison & No White Tiger (Report)

Diabetes & Tuberculosis: A Dangerous Liaison & No White Tiger (Report)

Diabetes mellitus (DM) is becoming a global epidemic and India, in particular, is noted as hosting a high proportion of this disease burden. There are approximately 41 million prevalent cases of DM in India and as per the International Diabetes Federation (IDF) estimates by 2025 this will rise to about 70 million, the largest number […]

Does Leptin have a Role in Immunity to Tuberculosis? (Commentary) (Report)

Does Leptin have a Role in Immunity to Tuberculosis? (Commentary) (Report)

Tuberculosis infection is acquired through inhalation of aerosolized infectious particles containing Mycobacterium tuberculosis, which can reach the alveoli in the distal airways. Macrophages and dendritic cells (DCs), the first host cells targeted by invading bacilli, are the key mediators of innate immunity to M. tuberculosis. In the course of infection, additional macrophages and resident DCs […]