The Use of Probiotics in the Prevention of Necrotizing Enterocolitis in Preterm Infants (Pharmacology Notes)

The Use of Probiotics in the Prevention of Necrotizing Enterocolitis in Preterm Infants (Pharmacology Notes)

Necrotizing enterocolitis (NEC) is defined as inflammation and necrosis of the bowel. It is the final manifestation of vascular, mucosal, and metabolic insults to the immature intestine (1, 2). NEC is a common gastrointestinal emergency in newborns and one of the leading causes of morbidity and mortality in neonatal intensive care units (NICU), with a mortality rate of 15% to 30% (3, 4). No single unifying theory exists for the pathogenesis of NEC that explains all the clinical observations associated with the disorder. Proposed mechanisms for the development of NEC include immature intestinal motility, digestion, circulatory regulation, barrier function, innate immunity, and abnormal bacterial colonization (2, 3).

The Use of Probiotics in the Prevention of Necrotizing Enterocolitis in Preterm Infants (Pharmacology Notes)



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